What is cancer?

Normally, cells in the body grow and divide in a controlled way when they're needed. Cancer starts when cells change (mutate) and grow out of control. The changed (abnormal) cells often grow to form a lump or mass called a tumor. Cancer cells can also grow into (invade) nearby areas. They can spread to other parts of the body, too. This is called metastasis.

How radiation therapy works

Radiation kills cancer cells over time by damaging the genes in the cells. It works best on cells that are growing fast, like cancer cells.

Radiation therapy is often given every day over many weeks. The goal is to kill as many cancer cells as possible. Radiation can also harm or kill normal cells that are close to the tumor. But damaged normal cells are better able to fix themselves than cancer cells. As treatment goes on, more cancer cells are killed than normal cells, and the normal cells fix themselves. Cancer cells can't fix themselves as well as normal cells. Over time, they die and are cleared by the body.

More cancer cells die.

As treatment ends, normal cells replace the cancer cells.

Types of radiation therapy

Different kinds of radiation therapy can be used to treat cancer. These are the three main ways radiation is given:

External beam radiation therapy

With external beam radiation therapy (EBRT), a large machine aims high-energy beams into the body and at the tumor. The goal of treatment is to kill all of the cancer cells while limiting damage to normal cells. The machine moves so it can send the beams into your body from any angle.

Newer types of EBRT focus the radiation more precisely at the tumor. This helps to protect nearby normal tissues. These newer types include:

• 3-D conformal radiation therapy (3-D CRT)

• Intensity-modulated radiation therapy (IMRT)

• Electron beam therapy

• Proton beam particle therapy

• Stereotactic radiosurgery or stereotactic ablative radiotherapy

Internal radiation therapy (brachytherapy)

Internal radiation uses radioactive needles, wires, seeds, or pellets that are put right into or near the tumor. These may be permanent (left inside the body) or temporary (the radioactive sources are removed after treatment).

The implants mean the radiation can be put very close to the cancer cells. This type of radiation travels only a very short distance. This helps focus the treatment on the cancer cells and spares nearby normal cells.

Systemic radiation therapy

Radiation therapy can be given as a liquid that's swallowed or put right into your blood through a vein. Or it can be given as an injection (shot) of tiny radioactive beads that are put into a vein (IV) or artery at the tumor (called radioembolization). Sometimes, the radiation is attached to a special antibody. This antibody binds to the cancer cells and targets them with radiation. It moves through the blood to reach tumors anywhere in the body. Once the radiation attaches to the cancer cells, it gives off small, controlled doses to kill the cancer cells.